Original Article

Clinical and Histologic Study of Sclerotherapy in the Rabbit Ear Vein Model : Basic Research for Treatment of Varicose and Telangiectatic Vein

Kyu-Kwang Whang
Author Information & Copyright
Department of Dermatology, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1995. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Mar 31, 1995

Abstract

Sclerotherapy has become a popular method for obliterating both varicose veins and telangiectases. Through the animal model of sclerotherapy, we would understand its mechanism as a basis of clinical application. Clinical and histologic changes were observed periodically after injecting the hypertonic saline into the dorsal marginal rabbit ear vein, and the results were as follows.

There was no color and diameter changes in the vein after the normal saline injection as a control. Clinical changes after injection of sclerosant were that the color of vein changed to blue or dark blue at the early period, and it eas faded out one month later. Histologic examination after injection of sclerocant showed the intravascular thrombosis, cutaneous necrosis, vascular proliferations, and fibrosis at the early period, and large vein was disappeared and replaced by several telangiectasis and matured fibrosis one month later.

We could predict the outcome clinically and histologically, and the complication like cutanceous necrosis should be warned during the clinical application.