| Type of liver injury | Hepatocellular | Points |
|---|---|---|
| Time of onset of the event | First exposure | |
| Time from drug intake until reaction onset | 5 to 90 days | +2 |
| Time from drug withdrawal until reaction onset | ≤15 days | +1 |
| Risk factors | No alcohol | +0 |
| Age ≥55 years | +1 | |
| Course of the reaction | >50% improvement 30 days | +2 |
| Concomitant therapy | None | +0 |
| Exclusion of nondrug-related causes | Rule out | +2 |
| Previous information on hepatotoxicity | Reaction published but unlabeled | +1 |
| Response to re-administration | Not done | +0 |
| Score analysis | Highly probable | +9 |