Table 3
Response rate to UDCA treatment according to various criteria and AMA positivity

Criteria Definition of Biochemical Response Evaluation of Time Point Rate of Biochemical Response (%)
Total (n=35) AMA positive (n=21) AMA negative (n=14)
Mayo [10] ALP <2.0xULN 6 Month 77.4% (24/31) 78.6% (13/17) 76.5% (11/14)
Barcelona [11] >40% decreased of 1 Year 69.2% (18/26) 66.7% (10/15) 72.7% (8/11)
ALP or normalization
Paris-1 [12] ALP <3.0xULN 1 Year 92.3% (24/26) 86.7% (13/15) 100% (11/11)
AST <2.0xULN and bilirubin ≤1 mg/dL
Momah/Lindor [13] ALP ≤1.67xULN and bilirubin ≤1 mg/dL 1 Year 76.9% (20/26) 66.7% (10/15) 90.9% (10/11)
ULN, upper limit of normal.