Criteria | Definition of Biochemical Response | Evaluation of Time Point | Rate of Biochemical Response (%) | ||
---|---|---|---|---|---|
Total (n=35) | AMA positive (n=21) | AMA negative (n=14) | |||
Mayo [ | ALP <2.0xULN | 6 Month | 77.4% (24/31) | 78.6% (13/17) | 76.5% (11/14) |
Barcelona [ | >40% decreased of | 1 Year | 69.2% (18/26) | 66.7% (10/15) | 72.7% (8/11) |
ALP or normalization | |||||
Paris-1 [ | ALP <3.0xULN | 1 Year | 92.3% (24/26) | 86.7% (13/15) | 100% (11/11) |
AST <2.0xULN and bilirubin ≤1 mg/dL | |||||
Momah/Lindor [ | ALP ≤1.67xULN and bilirubin ≤1 mg/dL | 1 Year | 76.9% (20/26) | 66.7% (10/15) | 90.9% (10/11) |