| Aminoglycoside | Target modification |
| Decreased permeability |
| Decreased accumulation |
| Enzymatic inactivation |
| Chloramphenicol | Enzymatic inactivation by acetyltransferase |
| Decreased permeability |
| Active efflux |
| Glycopeptide | Drug target alteration |
| β-Lactams | Modification of penicillin- binding protein |
| Decreased permeability |
| β-lactamase production |
| Macrolides, linezolid and streptogramin | Target modification |
| Decreased uptake and accumulation |
| Active efflux |
| Inactivation |
| Quinolones | Target (DNA gyrase) alteration |
| Decreased permeability |
| Active efflux |
| Rifampin | Inactivation of RNA polymerase |
| Drug alteration |
| Tetracycline | Target modification |
| Decreased permeability |
| Active efflux |
| Trimethoprim/sulfonamids | Increased production of insensitive dihydrofolate reductase/dihydrofolate synthase |
| Decreased permeability |
| Active efflux |