Original Article

The Effect of Halothane, Enflurane and Isoflurans on Hepatic Function in Acute Hypoxic Rats

Guie Yong Lee
Author Information & Copyright
Department of Anesthesiology, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1992. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015


The effects of halothane, enflurane and isoflurane on hepatic function in 50 Sprague-Dawley rats in the presence of acute mild hypoxic(oxygen 14%) condition were compared. Anesthetics were administered in 1 MAC halothane (1%), enflurane(2.2%), isoflurane(1.4%) with 40% oxygen for 1 hour, 24 hours later serum alaninie aminotransferase(ALT) and asparate aminotransferase(AST) measured. There were no statistically significant differences of ALT among study groups. There were significant differences of AST between hypoxic group and halothane, enflurane and isoflurane groups.

This study shows that admintistration of 40% oxygen with 1 MAC halothane, enflurane and isoflurane in acute mild hypoxic condition was not harmful on hepatic function.