Original Article

Evaluation of Microparticle Enzyme Immunoassay (MEIA) (ImRx, Abbott) in the Determination of Serum Thyrotropin (TSH)

Ki Sook Hong
Author Information & Copyright
Department of Clinical Pathology, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1993. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015


Microparticle enzyme immunoassay (MEIA) for thyrotropin (TSH) was evaluated and results were compared with those of immunoradiometric assay (IRMA) procedure. Coefficient of variations of within day precision was 3.8-9.6% and those of between day precision was 3.6-17.2%. Correlation between the MEIA(Y) and two site IRMA(X) was excellent (Y=1.0445X-0.1538, r=0.9948). The sensitivity of the assay (mean±2 SD of the zero standard) was 0,0158 µIU/ml. The concentration measured in 497 healthy subjects were ranged from 0.2-3 µIU/ml (mean 1.37 µIU/ml, SD 0.59).

Conclusively, MEIA is more fully automated than IRMA, well correlated with IRMA, can be reliable method for screening test of thyroid function.