Evaluation of Microparticle Enzyme Immunoassay (MEIA) (ImRx, Abbott) in the Determination of Serum Thyrotropin (TSH)
Published Online: Jul 24, 2015
Microparticle enzyme immunoassay (MEIA) for thyrotropin (TSH) was evaluated and results were compared with those of immunoradiometric assay (IRMA) procedure. Coefficient of variations of within day precision was 3.8-9.6% and those of between day precision was 3.6-17.2%. Correlation between the MEIA(Y) and two site IRMA(X) was excellent (Y=1.0445X-0.1538, r=0.9948). The sensitivity of the assay (mean±2 SD of the zero standard) was 0,0158 µIU/ml. The concentration measured in 497 healthy subjects were ranged from 0.2-3 µIU/ml (mean 1.37 µIU/ml, SD 0.59).
Conclusively, MEIA is more fully automated than IRMA, well correlated with IRMA, can be reliable method for screening test of thyroid function.