Original Article

An Experimental Study of the Effects of Cis-dichlorodiammineplatinum(II) and Irradiation on the Rat Livers

Seung Yon Baek, Kyung Ja Lee, Chung Sik Rhee
Author Information & Copyright
Department of Radiology, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1993. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015


Cis-DDP has been used as a radiosensitizer in combination treatment modality far malignanttumors, of which mechanism is uncertain. The efects of combined Cis-DDP and irradiationon number of tumors have been studied in vitro and in vivo. The effects of combined Cis-DDP and irradiation on the liver are important because the liver is a radiosensitive organand frequently exposed to irradiation during treatment for intra-abdominal malignancies. Butthe studies of combined Cis-DDP and irradiation on the liver have not been reported.

So, this study was peformed to see the effect of Cis-DDP in combination with radiationon the liver. Total 66 Sprague-Dawley rats were divided into 5 groups; control, Cis-DDP(2.5mg/kg) administration, radiation(6, 8, lOGy, respectively), and combined Cis-DDP and radia-tion. which consisted of pre- and post-administration of Cis-DDP. Light and electron microscopic examination was performed 30 days after each experiments.

Cis-DDP administration induced mild congestion and focal hemorrhage in hepatic lobuleswith focal necrosis and degeneration of hepatocytes. Electron microscopic examination showedirregular cytoplasmic organelles and chromatin clumping in hepatocytes. In radiation treatmentgroup. hemorrhage of hepatic lobules, necrosis and degeneration of hepatocytes, edema andinflammation in portal tracts were aggravated with increased dosage of radiation. Hepatic lobulardisarray and inflammatory cell infiltration in portal tracts were noted from 8 Gy radiation.Vacuoles and electron dense bodies as well as swollen mitochondria in hepatocytes were frequently noted on electron microscopic examination. With combined treatment all He light andelectron microscopic changes were more severe than radiation alone regardless of sequenceof Cis-DDP administration and lobular disarray and inflammation in portal tracts were startedto note with 6 Gy radiation. When the hepatic lobular disarray and inflammation in portaltracts were used as end-points. the enhancement ratio of Cis-DDP was 1.3 in normal rat livers.


We are pleased to announce the recent appointment of Dr. Sun Huh as the new editor-in-chief, starting in September 2023. Dr. Ryung-Ah Lee, who previously served as editor-in-chief, dedicated over a decade to her role from January 2013 to August 2023. Her diligent efforts were instrumental in establishing a robust and contemporary system for journal submission and publishing.

Dr. Sun Huh, a former President of the Korean Association of Medical Journal Editors (KAMJE), has graciously accepted the position at Ewha Medical Journal. You can explore his mission and goals as the editor-in-chief of EMJ in the editorial featured in this issue.

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