Original Article

Autopy Results of Clinically Diagnosed Alzheimer's Disease

Kyoung Gyu Choi
Author Information & Copyright
Department of Internal Medicine, College of Medicine, Ewha Woman's University, Korea.

Copyright ⓒ 1993. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015


Eight hundred and eighty four autopsy brains from patients with clinically diagnosed Alzheimer's disease were examined pathologically. Six hundred ninety eitht(79.96%) of the 884 cases fullfilled histological criteria for Alzheimer's disease, with or withour additional fndings, such as substantia nigral degeneration, cerebellar degeneration, Parkinson's disease or cerebral infarcts. One hundred and eighty six cases(20.04%) were diagnosed as other neurodegenerative disease such as Parkinson's disease, non-specific cortical degeneration or Pick's disease. Degenerative changes in the substantia nigra were common in patients with Alzheimer's disease than has been reported for the general aged population. Brain atrophy was severer in presenile type of Alzheimer's disease than in senile type of Alzheimer's disease.