Original Article

Hemostatic Effects of High-Dose Aprotinin in Open Heart Operations

Joung Taek Kim
Author Information & Copyright
Department of Thoracic and Cardiovascular Surgery, Ewha Womans University, Seoul, Korea.

Copyright ⓒ 1994. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Sep 30, 1994

Abstract

Two groups of patients were studied to evaluate the hemostatic effects of high-does aprotinin in open heart operations. Aprotinin group patients(n=8) received aprotinin during entire surgical procedure. The other group patients(n=10) were served as control. Two groups were homogenous for base variables and for cardiopulmonary bypass duration. Post operative bleeding was lower in aprotinin group(mean, 599ml) than control group(886ml, p<0.05). The need for banked blood decreased in aprotinin group(aprotinin group mean, 106ml ; control group mean, 387ml). Perioperative hemoglobin & platelet counts were similar each other.

We concluded that the use of high-does aprotinin was safe and effective. It decreased blood loss and reduced the need for banked blood in open heart operations.