The Expression of bFGF m-RNA in the Gastric Cancer Tissues

Kim, Young-Woo

doi:10.12771/emj.1999.22.1.17

Ewha Med J 1999; 22(1):17-21

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1999.22.1.17

Original Article

The Expression of bFGF m-RNA in the Gastric Cancer Tissues

Young-Woo Kim

Author Information & Copyright ▼

Department of Surgery, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1999. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Mar 30, 1999

Abstract

Backgrounds

The production of basic fibroblast growth factor(bFGF), which is known to have strong angiogenic activity in gastric cancer, was evaluated.

Methods

Using Alkaline phosphoatase-labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated with in situ hybridization method in 9 fresh advanced gastric cancer tissues.

Results

In situ Hybridization of bFGF mRNA showed positive reaction in 8 of 9 patients.

Conclusions

In view of profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.

Keywords: Gastric cancer; Basic fibroblast growth factor; In situ hybridization; mRNA