Effects of Topical Application of Oxymetazoline on Cultured Human Nasal Mucosa: Changes of Ciliary Activity and Histopathologic Findings
Published Online: Mar 30, 1999
Abstract
The aim of this study is to obtain the basic knowledge for safer clinical use of oxymetazoline, one of nasal decongestants, by observing changes of ciliary activity and histopa-thologic findings after topical application of oxymetazoline to the cultured human basak mucosa.
The nasal mucosa, obtained from the inferior tubinates in healthy non-smokers without any nasal symptoms or signs, was cultured and then, exposed to oxymetazoline solu-tion at different concentrations from 0.0123% to 0.25%, containing no preservatives. Ciliary activity was observed under an inverted microscope and the histopathology of the mucosa was examined by light microscopy 1,3,6,12,24 and 48 hours after exposure, respectively.
Oxymetazoline impaired ciliary activity and induced mucosal injury at dose- and time-dependent patterns. Once the ciliary activity disappeared, it was not restored at least for the next 48 hours. Furthermore, these functional and morphologic changes resulted from applying oxymetazoline at the concentration of clinical use.
Metrics
QR Code of this Article:
Related Articles
The Effects of Vero Cell Coculture on Mouse Oocyte Maturation and Embryo Development in Vitro
Ewha Med J 1996;19(3):425-432.
The Study of Intracellular Cyclic AMP and Protein in Cultured Human Melanocytes
Ewha Med J 1993;16(1):37-43.
Analysis of the Histopathology of the Irradiated Rat Brain with or Without Cisplatin in the First Post-Irradiation Month
Ewha Med J 1995;18(3):169-180.
Effect of Ethanol on the Neuronal Viability and Neurite Outgrowth in Primary Cultures of Rat Hippocampus
Ewha Med J 1995;18(4):335-342.
Fetal Cord Serum Supplemented Ham's F-10 vs. Medi-Cult for in Vitro Fertilization Culture Medium
Ewha Med J 1996;19(1):119-124.
