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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1988; 11(1):25-36

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1988.11.1.25

Original Article

Henoch-Schoenlein Nephritis and IgA Nephrogathy: A Comparison of Immunofluorescene and Electron Microscopic Study

Ok Kyung Kim
Corresponding author: Ok Kyung Kim. Department of Pathology, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1988. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The immunofluorescence and electron microscopic studies along with clinical presentation were performed and compared 1n 4 cases of Henoch-Schoenlein(HS) nephritis and 16 cases of IgA nephropagthy. The clinical and pathological findings of two conditions were similar. The light microscopic findings show more severe glomerular (high grade by ISKDC) change in HS nephritis than IgA nephropathy. The immunofluorescence study reveals exclusively IgA only or IgA with C3 deposition mainly at mesangium in IgA nephropathy, where as the HS nephritis show variable deposition of all immune globulin(IgA, IgC, IgM, C3, Fibrinogen, mainly mesangium associated with pericapillary area. Electron dense deposition in the mesangium were the most constant feature in IgA nephrogathy, where as variable extention of electron-dense peposition to the pericapillary, subepithelial and subendothelial area in HS nephritis were observed.