The Ewha Medical Journal
Ewha Womans University School of Medicine
Original Article

The Effect of Naloxone on Pathological Changes in the Experimental Spinal Cord Injury

Sung Hak Kim
Corresponding author: Sung Hak Kim. Department of Neurosurgery, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1988. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The object of this investigation was to study the effects of Naloxone on histopathological changes in cats subjected thoracic cord contusion. Twenty cats were divided 4 groups : The first group was sham control(3 Cats). The second group was the impact group that was induced by T9 cord injury without treatment(6 Cats). The third group was the saline group that was induced by T9 cord injury and treatment with Saline(6 Cats). The fourth group was the Naloxone group that was induced by T9 cord injury and treatment with Naloxone(6 Cats). The histopathological evaluation of the injured spinal cords in Naloxone-treated Cats had less tissue damage than would be observed in time-matched standards. The histopathology in Saline-treated group had slightly better than typical of what we would expect in impact group.

Keywords: Spinal cord injury; Ischemia; Naloxone