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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1989; 12(1):7-11

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1989.12.1.7

Original Article

The Effect of BHA and BHT on Mixed Function Oxygenase of Liver Tissue

Nak Eung Sung
Corresponding author: Nak Eung Sung. Department Biochemistry, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1989. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

To evaluate the effect of BHA and BHT on liver tissue, BHA and BHT, 100mg and 200mg/kg B.W. respectively, were given to experimental animals for 4 months.

Microsomal cytochrome P-450, cytochrome b5, cytochrome C reductase activity and lipid peroxidation of liver tissue of experimental animal were measured.

The results were as follow ;

1) Cytochrome P-450 increased significantly in experimental group given BHA but cytochrome b5 did not.

2) Cytochrome oxidnse activity increased moderately in BHA group but decreased in BHT group. From these finding, it can be assumed, that BHA and BHT has no great effect on human tissue.