The Ewha Medical Journal
Ewha Womans University School of Medicine
Original Article

Change of Biogenic Amine Contents in Lead Intoxicated Rat Brain

Kyung Gyu Choi, Byung-Chul Lee**

Copyright ⓒ 1992. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015


Lead is an neurotoxic substance and its clinical effect on the central nervous system has been well known since several decades ago. As the development of industry becomes more rapid and widespread in the world, we can expect the amount of lead and its harmful effect On the human life would increase in the future. We think the behavioural effect of lead on the central nervous system might be the result of the change of the neurotransmitters in the central nervous system. We studied the change of neurotransmitter amount in the cnetral nervous system of rats after lead intoxication. There was a significant neurotransmitter(catecholamine and 5 hydroxytryptamine) change after lead intoxication in our study.