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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1996; 19(4):459-462

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1996.19.4.459

Original Article

Amniotic Fluid Alpha-fetoprotein Levels in Midtrimester Pregnancies

Mi Hae Park, Young Ju Kim, Jung Ja Ahn, Bock Hi Woo

Copyright ⓒ 1996. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Objective

The purpose of this study is to establish the normal levels of α-fetoprotein in amniotic fluid between 15 and 22 weeks of gestation.

Method

Amniotic fluid Alpha-fetoprotein(AFAFP)levels were measured by enzyme-immunoassy in pregnant women between 15 and 22 weeks of gestation for variety of indication of amniocentesis from October, 1994 to July, 1996 at Mokdong Hospital Ewha Womans University.

The study group was selected from normal karyotype at prenatal genetic diagnosis and no congenital anomaly of fetus.

Results

The normal level of AFAFP was the highest at 16weeks and then it declined gradually as gestational weeks increased. The mean±SD levels of AFAFP from 15 to 22weeks were 16.9±5.7, 20.4±9.8, 13.8±6.8, 10.9±3.0, 8.1±2.3, 6.9±3.9, 5.6±1.6, 4.7±0.6µg/ml respectively, the median levels of AFAFP from 15 to 22weeks were 14.7, 16.2, 12.3, 11.0, 7.8, 5.5, 5.3, 4.8µg/ml, respectively.

Conclusion

We consider that this preliminary data normal AFAFP levels by each gestation weeks can be used as reference value for screening of anomalies or genetic disorder.

Keywords: Amniotic fluid; Alpha-fetoprotein(AFP); Midtrimester; Pregnauay