The Ewha Medical Journal
Ewha Womans University School of Medicine
Original Article

The Effect of Allopurinol and Veraoamil on the Peritoneal Adhesion Induced by Ligation of the Local Peritoneum in the Rats

Kum-Ja Choi

Copyright ⓒ 1998. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Dec 31, 1998

Abstract

Objectives & Methods

The postoperative peritoneal adhesions are associated with numerous complications, including small bowel obstruction, difficult and dangerous reoperations, and infertility. However the adhesion formation is inevitable phenomenon after abdominal surgery. In this study, a reproducible, quantitative rat model was developed that used uniform ischemic injury on the parietal peritoneum of the area over the right lateral thoracoepigastric vessles. The resulting adhesions and the inflammatory reaction of the insulted area were subsequently scored. And then two potential antiadhesive agents, allopurinol and verapamil, were tested and compared.

Results & Conclusion

The result suggest that verapamil appeared to be very effective in reducing adhesion formation but not with allopurinol. However, there was not significant relation to the severity of peritoneal adhesion and inflammatory reaction.

Keywords: Peritoneal adhesion; Antiadhesive agents