The Ewha Medical Journal
Ewha Womans University School of Medicine
Original Article

The Alterations of Na+·K+-ATPase Activity and Concentration of ATP Following Experimental Spinal Cord Trauma

Kyu Man Shin
Corresponding author: Kyu Man Shin. Department of Neurosurgery, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1983. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015


The author measured the activities of the membrane-bound enzyme, Na+·K+-ATPase, and ATP as a part of an attempt to define the major cellular alterations in the initial 4-hour period of the feline spinal cord following experimental impact injury with 400gm-cm. The activities of Na+·K+-ATPase were significantly decreased at post-injury 1-hour and between the 1-hour and 4-hour period. But for these same samples, the activities of Mg2+-ATPase did not change appreciably. Contents of ATP were significantly depleted in the same period. These changes suggested that this model of the spinal cord trauma results in a severe irrevirsible injury to the affected tissues.