Table 2
Guidelines for screening affected person with hereditary nonpolyposis colorectal cancer (HNPCC)

Screening	Recommendations
Colonoscopy	Every 1–2 yr beginning at age 20–25 yr or 2–5 yr younger than youngest age at diagnosis of colorectal cancer in family if diagnosis before age 25 yr
	Considerations:
	Start at age 30 yr in MSH6 and 35 in PMS2 families
	Annual colonoscopy in mismatch repair mutation carriers
Pelvic examination with endometrial sampling	Annually beginning at age 30–35 yr
Transvaginal ultrasound	Annually beginning at age 30–35 yr
Esophagogastroduodenoscopy with biopsy of the gastric antrum	Beginning at age 30–35 yr and subsequent surveillance every 2–3 yr can be considered based on patient risk factors
Urinalysis	Annually beginning at age 30–35 yr