Heart failure | Contraindication in NYHA class III-IV | Contraindication in NYHA class III-IV | Contraindication in NYHA class III-IV | Contraindication in severe heart failure | Contraindication in congestive heart failure | Contraindication in congestive heart failure | Contraindication in congestive heart failure |
Renal insufficiency CrCl (mL/min) GFR (mL/min/1.73m2) | - | Contraindication: <30 mL/min | Contraindication: <30 mL/min | Contraindication: <30 mL/min | Contraindication: <30 mL/min/1.73m2 | Contraindication: <30 mL/min/1.73m2 | Contraindication in severe renal insufficiency |
Ascites | - | - | - | - | Contraindication | Contraindication | Contraindication |
Hypermagnesemia | - | - | - | - | - | - | Contraindication |
Phenylketonuria | - | Contraindication | Contraindication | Contraindication | - | - | - |
Glucose-6-phosphate deficiency | - | Contraindication | Contraindication | Contraindication | - | - | - |
Severe ulcerative colitis | Caution | Caution | Caution | Caution | Caution | Caution | Contraindication |
Gout | - | - | - | - | Risk of gout attack owing to transient elevation of uric acid levels | Risk of gout attack owing to transient elevation of uric acid levels | - |
Pregnant females | Insufficient evidence to safety | Insufficient evidence to safety | Insufficient evidence to safety | Insufficient evidence to safety | Insufficient evidence to safety | Insufficient evidence to safety | Insufficient evidence to safety |
Breastfeeding females | Excreted into breast milk | Excreted into breast milk | No reports | No reports | No reports | No reports | No reports |