| Pamidronate (second generation) | Intravenous (in 200–250 mL saline in 3–4 hours) | 0.5–1 mg/kg/day, 2–3 consecutive daysevery 2–4 months9–11.5 mg/kg/yearMaximum: 60 mg/dose | 100 |
| Alendronate (second generation) | Oral | 1–2 mg/kg/week<40 kg: 5 mg/day or 35 mg/week>40 kg: 10 mg/day or 70 mg/weekMaximum: 70 mg/week | 100–1,000 |
| Neridronate (third generation) | Intravenous (in 200–250 mL saline in 3 hours) | 1–2 mg/kg/day every 3–4 monthsMaximum: 100 mg/dose | 100 |
| Zoledronate (third generation) | Intravenous (in 50 mL saline in 30–45 minutes) | 0.025–0.5 mg/kg every 6–12 monthsMaximum: 4 mg/dose | >10,000 |