| Pedrazzani et al. [40] | 2019 | Retrospective cohort | Aged ≤65 vs. 66−75 vs. ≥76 | 112 vs. 57 vs. 56 | Laparoscopic colorectal resection +ERAS | No difference | Overall: 25.9% vs. 36.8% vs. 42.9%, Major: 4.5% vs. 3.5% vs. 1.8% (NS) anastomotic leak : 2.7% vs. 1.8% vs. 1.8% (NS) | Lower compliance in the elderly group with early ambulation, early Foley removal, stopping fluids, and opiate avoidance |
| Chan et al. [41] | 2020 | Retrospective cohort | Aged <65 vs. ≥65 | 75 vs. 97 | Colorectal cancer resection (laparoscopy 83.7%) | 6.7 vs. 10.9 days, P=0.007 | 16.0% vs. 33.0%, P=0.011 | Deviation from ERAS: 6.7% vs. 15.5% (P=0.074) |
| Koh et al. [42] | 2022 | Retrospective cohort | Aged ≤70 vs. >70 | 237 vs. 98 | Colorectal cancer surgery (MIS: 95.8%) | No difference | Morbidity calculated by the CCI score, no difference | Significantly more comorbidities in the older group |
| Tejedor et al. [43] | 2018 | Retrospective cohort | ERAS vs. non-ERAS (case-matched) | 156 vs. 156 | Colorectal surgery, aged ≥70 (laparoscopy 59% vs. 21%, P<0.0001) | 6 (5.25) vs. 8 (6.75) days P<0.0001 | Major complications: 10.3% vs. 21.8%, P=0.020 Mortality: 1.9% vs. 11.5%, P=0.001 | Compliance with the ERAS protocol in the ERAS group: 42% |
| Martínez -Escribano et al. [44] | 2022 | Retrospective cohort | Pre-ERAS vs. ERAS | 158 vs. 213 | Colorectal cancer resection (aged ≥70, laparoscopy 46.5% vs. 65.7%) | No difference, lower ICU admission in ERAS (OR 0.42, 95% CI 0.27−0.65, P<0.001) | No difference | A lower transfusion rate in ERAS (OR 0.26, 95% CI 0.14−0.48, P<0.001) |