The Ewha Medical Journal
Ewha Womans University School of Medicine
Case Report

A Case of Type II Membranousproliferative Glomerulonephritis with Hump (Dense Deposit Disease)

Hee Jung Oh, Min A Yu, Young Sook Lee, Mi Yoen Kim, Seung Jeong Kim, Duck Hee Kang, Gyeon Il Yun, Kyu Bok Choi, Sun Hee Sung

Copyright ⓒ 2004. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Mar 30, 2004

Abstract

Dense deposit disease (DDD), known as type II MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of type I MPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.

Keywords: Dense deposit disease; Type II MPGN; Subepithelial hump