The Ewha Medical Journal
Ewha Womans University School of Medicine
Original Article

A Study of Effect of Recirculation in Experimental Cerebral Ischemia

Kyu Man Shin
Corresponding author: Kyu Man Shin. Department of Neuropsugery Ewha Womans University College of Medicine, Seoul, Korea.

Copyright ⓒ 1985. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Focal cerebral ischemia initiates a series of event from the regional development of ischemic edema, loss of neural function and culminating in eventual infarction. The purpose of this study is to determine the effect of recirculation in acute focal cerebral ischemia. Sixty adult mongrel cats of either sex underwent production of focal ischemia by transorbital occlusion of the left middle cerebral artery with a Heifetz clip. The duration of ischemia was 1, 3 and 5 hours. In 5 animals in each group, the ischemic brain was reperfused for 1, 4 and 7 hours by removing the clip from the artery. It was observed that provided the restoration of cerebral blood flow in cats can be accomplished within 1 hour in cats or at least within 3 hours of the insult, the reversal of the neurological deficits and prevention of irreversible cerebral infarction can be expected. Therefore the prevention of cerebral infarction must first be directed toward improving blood flow during the insult as rapidly as possible to-minimize the time that cerebral blood flow is below threshold for the formation edema.