Chronosomal Abnormalities in Patients with Hemato-Oncologic Disease: Analysis of 42 Cases
Published Online: Jul 24, 2015
With development of new technology such as handing technique and high resolution banding technique, cytogenetic examination has been utilized greatly in diagnosis and treatment of patients with hemato-oncologic diseases.
Forty two patients with newly diagnosed and previously untreated hemato-oncologic diseases were examined for chromosomal abnormalities which included 11 cases of acute myelogenous leukemia(AML). 7 cases of acute lymphoblastic leukemia (ALL) and myelodyspalstic syndrome (MDS) each, 6 cases of chronic myelogenous leukemia (CML). 5 cases of other myelolproliferative disorders(MPD). 4 cases of non-Hodgkin's lymphoma(MHL). and 1 case each of aplastic anemia(AA) and malignant schwannoma(MS).
Two cases of AML(18.2%) showed 45 XO and aneuploidy. Four cases of ALL(55.5%) showed chromosomal abnormalities : 3 cases with Philadelphia chromosome and 1 case with 45 XO.
Only one case of MDS(14.3%) showed trisomy 8 and none of 3 cases which were converted to AML showed chromosomal abnormalities. Five cases of CML(83.3%) showed Philadelphia chromosome. Chromosomal abnormalities were not noted in cases of MPD, MHL, AA and MS.
Collective studies of chromosomal abnormalities in hemato-onclologic diseases should be investigated further.