Case Report
A 67-year-old man with gastric adenocarcinoma with enteroblastic differentiation in Korea: a case report
Hae Rin Lee1,2, Gwang Ha Kim1,2,3,*, Dong Chan Joo1,2, Moon Won Lee1,2, Bong Eun Lee1,2, Kyung Bin Kim4
1Division of Gastroenterology, Pusan National University Hospital, Busan 49241, Korea.
2Department of Internal Medicine, Pusan National University School of Medicine, Busan 49241, Korea.
3Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea.
4Department of Pathology, Pusan National University Hospital, Busan 49241, Korea.
*Corresponding Author: Gwang Ha Kim, Division of Gastroenterology, Pusan National University Hospital, Busan 49241, Korea, Republic of. Department of Internal Medicine, Pusan National University School of Medicine, Busan 49241, Korea, Republic of. Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea, Republic of. Phone: +82-51-240-7869. E-mail:
doc0224@pusan.ac.kr.
© Copyright 2024 Ewha Womans University School of Medicine. This is an Open-Access article distributed under the terms of the
Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits
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Received: Apr 04, 2024; Revised: Apr 19, 2024; Accepted: Apr 19, 2024
Published Online: Apr 30, 2024
Abstract
Gastric adenocarcinoma with enteroblastic differentiation (GAED), also known as clear cell gastric carcinoma, is a rare and poorly documented malignancy. GAED is a subtype of alpha-fetoprotein (AFP)-producing adenocarcinoma. The histological characteristic of GAED is an intestine-like structure composed of cuboidal or columnar neoplastic cells with clear cytoplasm that stain positive for oncofetal proteins including glypican-3, spalt-like transcription factor 4, and AFP. Compared with conventional adenocarcinoma, GAED demonstrates a more aggressive behavior due to frequent lymphovascular invasion and a high rate of metastasis to the liver and lymphatics. Therefore, clinicians should be aware of the histopathological diagnosis of this rare tumor and its aggressive behavior. Herein, we report a rare case of GAED that was treated with endoscopic submucosal dissection and additional distal gastrectomy with lymph node dissection.
Keywords: Gastric cancer; Adenocarcinoma with enteroblastic differentiation; Clear cell gastric carcinoma