A 67-year-old man with gastric adenocarcinoma with enteroblastic differentiation in Korea: a case report
Received: Apr 04, 2024; Revised: Apr 19, 2024; Accepted: Apr 19, 2024
Published Online: Apr 30, 2024
Abstract
Gastric adenocarcinoma with enteroblastic differentiation (GAED), also known as clear cell gastric carcinoma, is a rare and poorly documented malignancy. GAED is a subtype of alpha-fetoprotein (AFP)-producing adenocarcinoma. The histological characteristic of GAED is an intestine-like structure composed of cuboidal or columnar neoplastic cells with clear cytoplasm that stain positive for oncofetal proteins including glypican-3, spalt-like transcription factor 4, and AFP. Compared with conventional adenocarcinoma, GAED demonstrates a more aggressive behavior due to frequent lymphovascular invasion and a high rate of metastasis to the liver and lymphatics. Therefore, clinicians should be aware of the histopathological diagnosis of this rare tumor and its aggressive behavior. Herein, we report a rare case of GAED that was treated with endoscopic submucosal dissection and additional distal gastrectomy with lymph node dissection.
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