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Ahead-of print article

Articles in the epub version are posted online ahead of regular online publication.

Editorial

[English]
Building on a strong foundation: a new chapter for the Ewha Medical Journal
Ji Yeon Byun
Received January 26, 2026  Accepted January 27, 2026  Published online January 30, 2026  
DOI: https://doi.org/10.12771/emj.2026.01130    [Epub ahead of print]
  • 79 View
  • 5 Download

Review article

[English]
Revisiting the multiple roles of T-cadherin and adiponectin in cardiovascular disease: from receptor function to exosome-mediated therapeutic potential
In Sook Kang
Received December 3, 2025  Accepted January 19, 2026  Published online January 29, 2026  
DOI: https://doi.org/10.12771/emj.2025.01067    [Epub ahead of print]
Cardiovascular disease, particularly ischemic heart disease, remains a leading cause of death worldwide. Although advances in pharmacological and device-based therapies have improved clinical outcomes, effective strategies for myocardial repair and regeneration remain limited. T-cadherin, a glycosylphosphatidylinositol-anchored atypical cadherin, has recently been identified as a functional receptor for both low-density lipoprotein cholesterol and adiponectin, a cardioprotective adipokine. Notably, the interaction between T-cadherin and adiponectin has emerged as a key regulator of exosome biogenesis and paracrine signaling within cardiovascular tissues. Exosomes are nanosized extracellular vesicles that carry protective molecular cargo, including microRNAs and proteins, and contribute to anti-inflammatory, antifibrotic, and angiogenic effects in the ischemic myocardium. However, their clinical translation is challenged by factors such as variability in yield, heterogeneity of exosome populations, and inefficient tissue targeting. Enhancing endogenous exosome production through the T-cadherin–adiponectin pathway may therefore offer a novel cell-free therapeutic strategy. This review explores the biological roles of T-cadherin and adiponectin in cardiovascular diseases, their regulatory influence on exosome formation, and the future potential of leveraging this axis for myocardial repair and regeneration.
  • 69 View
  • 1 Download

Original articles

[English]
Immunohistochemical expression of Ki-67, estrogen receptor, and human epidermal growth factor receptor 2 in p16-positive premalignant and malignant cervical squamous lesions: associations with clinicopathological parameters
Ashwini Pitambra, Jitendra Singh Nigam, Immanuel Pradeep, Ashutosh Rath, Seetu Palo, Naina Kumar
Received December 10, 2025  Accepted January 19, 2026  Published online January 28, 2026  
DOI: https://doi.org/10.12771/emj.2025.01088    [Epub ahead of print]
Purpose
Human papillomavirus is the dominant etiological factor underlying atypical cervical squamous epithelial cell abnormalities and cervical carcinoma. Currently, only a limited number of drugs targeting specific biomarkers in cervical cancer are available. This study aimed to assess the expression of estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), and the Ki-67 proliferative index (Ki-67) in p16-positive cervical squamous premalignant and malignant lesions, which may help clarify the potential role of targeted therapies in cervical cancer.
Methods
In p16-positive, histologically proven premalignant and malignant cervical lesions, ER, HER2, and Ki-67 expression were evaluated according to predefined criteria.
Results
p16 showed strong nuclear and cytoplasmic positivity in 54 of 56 cases. Patchy nuclear positivity was mainly observed in low-grade squamous intraepithelial lesion (LSIL) cases (2/56). Ki-67 demonstrated a variable proliferative index ranging from 5% to 95% across all cases, with higher indices predominantly observed in squamous cell carcinomas (SCC). ER positivity in LSIL, high-grade squamous intraepithelial lesion, and SCC was 100% (2/2), 66.7% (10/15), and 46.15% (18/39), respectively. HER2 expression was predominantly negative, observed in 78.6% (44/56) of cases, equivocal in 17.8% (10/56), and positive in 3.6% (2/56). Both HER2-positive cases were SCC. ER and HER2 interpretations were analyzed and were not significantly correlated with clinical or pathological parameters.
Conclusion
ER positivity decreased with progression of cervical squamous lesions, and HER2 expression was rare in cervical squamous neoplasia. No statistically significant correlation was identified between ER or HER2 expression and clinicopathological parameters. The findings of the current study may help fill gaps in the existing literature and provide essential foundational knowledge for optimizing emerging therapeutic strategies, including ER- and HER2-related therapies.
  • 132 View
  • 11 Download
[English]
Endoscopic vacuum therapy for gastrointestinal transmural defects: clinical outcomes and treatment implications: a retrospective study from Korea
A Reum Choe, Ki-Nam Shim, Ju-Ran Byeon, Yehyun Park, Eun Mi Song, Chung Hyun Tae, Sung-Ae Jung
Received November 29, 2025  Accepted January 8, 2026  Published online January 21, 2026  
DOI: https://doi.org/10.12771/emj.2025.01025    [Epub ahead of print]
Purpose
Endoscopic vacuum therapy (EVT) has emerged as a highly effective approach for managing gastrointestinal transmural defects and may offer advantages over traditional methods, such as stenting. This study evaluated the clinical outcomes of EVT for gastrointestinal transmural defects resulting from leakages, perforations, and fistulas.
Methods
We retrospectively reviewed patients who underwent EVT for gastrointestinal transmural defects at Ewha Womans University Medical Center between February 2018 and September 2025 and analyzed clinical outcomes, adverse events, and risk factors associated with adverse events.
Results
Fourteen patients were included (mean age, 63.9 years; 85.7% male). Stomach surgery was the most common etiology (50.0%), and malignancy accounted for 71.4% of cases. The median number of EVT sessions was 2.5, and the mean interval from the index event to the first EVT session was 10.5 days. EVT achieved a 100% technical success rate, with no 30-day mortality; there was 1 in-hospital death (7.1%), 2 cases of stricture (14.3%), and 1 major bleeding event (7.1%). Adverse events were observed more frequently in patients who underwent ≥3 EVT sessions (57.1%) compared with those who underwent <3 sessions, in whom no adverse events occurred.
Conclusion
This study suggests that EVT is a safe and effective treatment for gastrointestinal transmural defects, with high technical success rates. The number of EVT sessions and the timing of treatment initiation appeared to be associated with complications and overall clinical outcomes.
  • 89 View
  • 3 Download

Correspondance

[English]
The spirit of Ewha, carried forward through devotion: an interview with Dr. Kumie Oh, alumna of the 27th graduating class, anesthesiologist
Nahyun Kwon, Jiyoon Kim
Received November 24, 2025  Accepted December 24, 2025  Published online January 13, 2026  
DOI: https://doi.org/10.12771/emj.2025.01018    [Epub ahead of print]
  • 94 View
  • 3 Download

Opinion

[English]
Norovirus infection control in Korea: points to consider
Joowon Lee
Received November 24, 2025  Accepted December 31, 2025  Published online January 13, 2026  
DOI: https://doi.org/10.12771/emj.2025.01011    [Epub ahead of print]
  • 107 View
  • 1 Download
Case report
[English]
Positional and ventilatory mechanics in the unexpected resolution of glycopyrrolate-induced tachycardia: a case report
Seung Ju Ahn, So Young Lee
Received November 5, 2025  Accepted December 24, 2025  Published online January 13, 2026  
DOI: https://doi.org/10.12771/emj.2025.00983    [Epub ahead of print]
A 28-year-old woman developed drug-induced tachycardia in the left lateral decubitus (LLD) position following intravenous administration of glycopyrrolate. The tachycardia was unresponsive to esmolol, labetalol, and fentanyl but resolved unexpectedly after the tidal volume was reduced from 8 to 6 mL/kg. Drug-induced tachycardia or arrhythmia occurring in the LLD position under mechanical ventilation may be attenuated by adopting a low tidal volume ventilation strategy (6 mL/kg).
  • 100 View
  • 1 Download
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