, Sung Sook Kim This study was aimed to assess the value of rapid urease test (CLO test) for thedetection of Helicobacter (H.) pylori in patiens with duodenal ulcer and compare its resultwith histological technique using H & E stain.
The CLO test and histological study were done using three pieces of antral biopsyspecimens in 46 patients with duodenal ulcer. The clinical histories such as smoking, bloodtype or the previous use of NSAIDs were obtained from the patients.
1) The CLO test was positive in 35 (76.1%) among 46 patients with duodenal ulcer, while H & E stain was positive in 91.3%.
2) When H & E stain positive case was diagnosed as H. pylori infection, the sensitivity of CLO test was 81.0%, the specificitry 75.0% and the predictability was 97.1%.
3) The grading of gastric inflammation showed that the higher the histologogical grade, the more likely CLO test would be positive.
4) There were no differences of recurring history of duodenal ulcer, smoking rate, NSAIDs history and blood type between 34 cases of both CLO and H & E positive cases and 3 cases ofboth negative cases except a mild increasing tendency of age, male predominance and scarringstage of duodenal ulcer in both negative cases.
The CLO test is a rapid and simple test, but it should require other complementary diagnostic tests to increase the sensitivity and specificity.
Sydney system in the classfication of histologic gastritis recommends the grading of
One hundred consecutive endoscopy patients had two antral biopsies for CLO test and histopathologic examination.
1) CLO test was positive in 52 among 100 cases(52%) and among the CLO test positive cases, forty five(86.5%) became positive within 1 hour.
2) The positive rate of the CLO test increased according to the grade of
3) The group(n=45) who turned positive within 1 hour showed higher grade of
It was thought that the grade of histologic gastritis reflected the positive rate of the CLO test and reaction time to a positive CLO test is related to
, Young Mee Ahn, Doe Young Kim, Il Whan Moon Although CLO test is one of the most commonly used rapid urease test for the diagnosis of
One hundred and eight patients underwent gastroscopy and two biopsy specimens from the greater curvature of the antrum was used for HP test and CLO test. Another biopsy specimen from lesser curvature of midbody was used for HP test. We read them at 20min, 1hour, 3hours, and 24hours.
The positive rate of HP test in antrum was 49.1%(53/108) which was the same as CLO test in antrum. The concordance rate of the results of two tests in the same site(antrum) were 98.2%. In terms of a time change to a positive test, both tests were not significantly different with each other. ; 3hour positive rate of HP test was 94.4% and that of HP test was 92.5%. Four patients(5.6%) performed HP test had positive results after 2hours known final reading time.
The positive rate of HP test in body was 52.8%(57/108) and that of HP test in antrum or body was 53.7%(58/108). The concordance rate of the results of antrum and body in HP test was 94.4%. Five of the negative HP test in antrum(4.7%) had positive results in gastric body. They were negative CLO test in antrum.
In conclusion, HP test was thought to be as valuable as CLO test for the diagnosis of
, Il Hwan Moon CLO test™ is simple, rapid and a commonly used rapid urease test for the diagnosis of
From January 1996 to January 1998, 1,370 cases of CLO test were performed. A gastric biopsy specimen from the greater curvature of antrum within 2cm from pylorus was used for CLO test.
The proportion of performed CLO tests among total endoscopic examinations was 14.1%(1,370/9,709). The most common indication of CLO test was duodenal ulcer, followed by chronic gastritis and gastric ulcer in order. In male, duodenal ulcer was the most common indication of CLO test, while in female, chronic gastritis was the most common. The positive rate of CLO test of total 1,370 cases was 62.0%. The positive rate of CLO test in male was significantly higher than that in female and the 4th decade of age showed the highest prevalence. According to the endoscopic diagnosis, the positive rate of CLO test was the highest in active stage of duodenal ulcer(84.3%), 56.5% in gastric ulcer, 54.6% in chronic gastritis, and 52.8% in gastric cancer. Comparing between 1996 and 1997, the number of CLO test increased, but its positive rate decreased significantly.
Although the most common indication of CLO test was duodenal ulcer in this study, the result that CLO test was also commonly used in chronic gastiritis implies an increasing interest about the role of
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