, Joo Ho Lee, Yun Bin Lee, Hana Park, Seong Gyu Hwang, Kyu Sung Rim Acute clinical deterioration in patients with chronic liver disease is called acute on chronic liver failure (ACLF). Principles of management of ACLF consist of early identifying etiology of liver disease, rapid intervention of precipitating event and discreet intensive cares. Despite medical intensive cares, if liver failure progresses, liver transplantation could be the other option. Also, liver transplantation is the only treatment that offers a chance of cure for hepatocellular carcinoma (HCC) and the underlying liver cirrhosis simultaneously. Emergent living donor liver transplantation (LDLT) can be performed for patients with acute liver failure and improves survival rate, especially in circumstances which liver graft is often not available because of deceased donors are not affordable. Here, we describe a chronic hepatitis B patient who developed ACLF accompanying early HCC. Because he did not improved with medical care, he received emergent LDLT. After LDLT, he showed great improvement without critical complications.
Citations
, Tae Hun Kim, Woon Sup Han Chronic HBV infection is the main cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma in Korea. Hepatic flbrosis progresses as the duration of HBV infection prolongs therefore more advanced histologic findings are anticipated in patients with perinatally acquired HBV infection than in patients of the same age who acquired HBV otherwise. We are going to investigate the histologic findings of young adult patients with chronic hepatitis B with respect to maternal HBsAg status, duration of HBV possession and senun HBeAg starus and ALf levels.
A total of 96 HBsAg positive young adult male patients who visited our hospital forliver biopsy were enrolled and their histologic findings were analysed according to the standardcriteria. The medical records of the patients were reviewed and supplementary information weretaken via telephone interviews.
Hepatic inflammatory scores and fibrosis stages were increased as the serum ALf level increased. Histologic findings showed no significant differences according to the duration of HBV infection, serostatus of HBeAg, the number of HBsAg positive cells and matemal senun HBsAg status.
In young adult patients with chronic hepatitis 3, the hepatic histologic findings were worsen as the serum ALf level increased and associated with neither the HBeAg status of the patient nor the matemal HBsAg status.
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