, So-Youn Woo Epstein-Barr virus(EBV) is associated with development of various types of lymphoma, especially NK/T cell lymphoma. Recently, its subtypes and LMP-1, major oncoprotein of EBV, have been studied. We investigated the frequency of EBV, its subtypes, and LMP-1 status on the cases diagnosed at Ewha university hospital between 1993 and 2002.
Sixteen cases of NK/T cell lymphomas were studied. In situ hybridization for EBER-1 mRNA and PCR for EBV subtypes and 30 base pair deletion of LMP-1 were done.
All cases showed EBV positivity by EBER in situ hybridization. All cases contained Type A viruses and 10 cases(62.5%) revealed LMP-1 30bp deletion.
EBV act as a causative role in the development of NK/T cell lymphoma. The exact role of LMP-1 30bp deletion variant in the lymphomatogenesis should be studied with larger number of cases.
, Doe-Young Kim Infectious mononucleosis is an acute lymphoproliferative disease that is most common in children and young adults and is caused by Epstein-Barr virus.
Characteristic clinical feastures include : 1) fever, sore throat, and lymphadenopathy ; 2) an associated absolute lymphocytosis greater than 50%, of which at least 10% are atypical lymphocytes in the peripheral blood ; 3) development of transient heterophil and persistent antibody responses against Epstein-Barr virus ; and 4) abnormal liver function tests.
The most prevalent age of infectious mononucleosis in Korea was less than 5 years old and it has been very rare in adulthood. However, recently in Korea, possibly due to the increasing number of people who are non-immune to Epstein-Barr virus, the age range seems to be increasing from young childhood to over 10 years old and even to adulthood. We present a 19-year-old man who showed typical clinical features of infectious mononucleosis.
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