We presented here a patient of autoimmune hemolytic anemia associated with systemic lupus erythematosus. This 38 year old female was admitted because of dizziness and dyspnea. In peripheral blood and bone marrow study, characteristics of autoimmune hemolytic anemia were seen. And she was well treated with prednisolone only. The general concept of autoimmune hemolytic anemia with the brief review of literature is discussed.