The purpose of this study was to compare the safety and efficacy of midazolam sedated Endoscopic retrograde cholangiopancreatography (ERCP) with unsedated ERCP in patients 70 years of ages and older.

Seventy elderly patients 70 years of age or older who underwent ERCP were divided into two groups: midazolam sedated group (n=43) and unsedated group (n=27). Procedure time, success rate, complications related with ERCP procedure, satisfaction score were analyzed between two groups.

Mean procedure time was 20.6 minutes for sedated group and 21.0 minutes for unsedated group (P=0.88). Success rate was 87.5% for sedated group and 100% for unsedated group (P=0.07). Incidence of complications from ERCP procedure showed no significant differences between the sedated and unsedated groups (P=0.10). There was no mortality in both groups related to the sedation or post-ERCP complication. Compared to the unsedated procedure, the sedated ERCP procedure was associated with higher patient satisfaction (P<0.001) and better repeat compliance (P=0.004).

There was no significant difference in success rate and complications at sedated and unsedated ERCP in patients 70 years of age and older. Unsedated ERCP showed 66.6% satisfaction score compared to sedated ERCP.

As the general population ages increase leading to an increase in the demand for therapeutic ERCP interventions. The aims of this study are to assess the outcomes, safety and complications associated with ERCP performed in elderly patients.

ERCP was performed in 287 patients aged 70years or over from Jan. 2000 to Dec. 2005. All the patients were evaluated and retrospectively reviewed. The main indications, complications, success rate, mortality and risk factors of procedure were analysed.

287 patients(162 females and 122 males, mean age 78 years, range 70-94years) underwent diagnostic and therapeutic ERCP. Mortality rate was 0.03% and success rate was 91.7%. Minor complications including procedure-related complications such as pancreatitis(2.8%), minor bleeding(1.4%), and aggravated cholangitis(2.1%), mild hypoxia(SaO₂ < 90%, 15.1%), premature ventral contraction(1.0%), and tachycardia(50.7%) were transient. Major events were presented as severe hypoxia(SaO₂ < 85%) in three pts(1.0%), and atrial fibrillation in one patients (0.03%).

This study showed that diagnostic and therapeutic ERCP is safe in elderly patients. Minor complications are usually transient and mortality is similar to previous reported rate.

Sydney system in the classfication of histologic gastritis recommends the grading of Helicobacter(H.) pylori density, activity and chronic inflammation. CLO test is a rapid urease test to diagnose H. pylori infection. The relation between the grading of gastritis and the positivity of the CLO test has not been well studied. Accordingly, this study was performed to investigate the positive rate of the CLO test according to the grade of gastritis.

One hundred consecutive endoscopy patients had two antral biopsies for CLO test and histopathologic examination. H. pylori density, activity and inflammation were each graded into 0, 1, 2, and 3.

1) CLO test was positive in 52 among 100 cases(52%) and among the CLO test positive cases, forty five(86.5%) became positive within 1 hour.

2) The positive rate of the CLO test increased according to the grade of H. pylori density, mucosal activity and chronic inflammation.

3) The group(n=45) who turned positive within 1 hour showed higher grade of H. pylori density than the group(n=7) who turned positive from 1 to 24 hour.

It was thought that the grade of histologic gastritis reflected the positive rate of the CLO test and reaction time to a positive CLO test is related to H. pylori density.

Despite of recent advances in pharmacological treatment and improvement surgical and anesthetic techniques, subarachnoid hemorrhage(SHA) from ruptured intracranial aneurysms with poor clinical grades still carries unacceptably high morbidity and mortality rates. Recently surgery for aneurysmal SAH with poor clinical grade has increased interest.

The authors experienced 57 patients with poor clinical grade (Hunt and Hess grade IV-V) after ancurysmal SAH. Among them 25 patients were treated with immediate CSF drainage via ventriculostomy, blood pressure control, early angiography(except 3 patients) and surgery within 12 hour of admission.

The outcomes of patients were categorized using a four-tiered scale :

1) independent and working

2) impaired but independent

3) severly impaired and dependent

4) dead

The average age was 48(13-75) and the male to female ratio was 7:18 in surgical group. The average time to admission and surgery was 12 hours or less among the 25 patients. Among them 9 cases were dead, 2 cases were severly impaired and dependent, 3 cases were impaired but dependent, and 11 cases were independent and working. In this patient all cases, exception one could be ligated with a clip.

The above results suggest that the acute aggressive surgery based on appropriate selection in poor aneurysmal SAH patients can reduce of the mortality.

Tumor lysis syndrome(TLS) has been broadly defined as the metabolic abnormalities that occur after rapid tumor breakdown. The purpose of this study was to evaluate the types or degrees of metabolic abnormalities and clinical characteristics in patients with high-grade non-Hodgkin's lymphoma(NHL) who developed clinical TLS.

Patients were considered to have 'clinical TLS' if two of the following metabolic abnormalities occurred within 4 days of treatment : a 25% increase in the serum phosphate, potassium, uric acid, urea nitrogen concentrations, or a 25% decline in the serum calcium concentration and one of the following : a serum potassium level greater than 6.0mEq/L, a creatinine level greater than 2.5mg/dL, a calcium level less than 6.0mg/dL, the development of a life-threatening arrhythmia, or sudden death.

Clonical TLS occurred in 15 patients with advanced high-grade NHL, and these patients were associated with elevated lactate dehydrogenase(LDH) and β₂-mivtonlonulin(MG)levels. Pre-treatment TLS occurred in 10 patients(66.7%) and post-treatment TLS in 5 patients(33.3%). Most of these patients showed metabolic abnormalities including hyperuricemia, hyperphosphatemia, hypocalcemia, or acute renal insufficiency. They were treated with adequate hydration combined with allopurinol and recovered in 4 patients. In remained 11 patients, hemodialysis was required and the metabolic parameters returned to normal levels without any significant complications.

It is important to remember that patients with advanced high-grade NHL who have more increased serum LDH or β₂-MG level be carefully monitored. Further investigations of elucidating risk factors and diagnostic criteria on clinical TLS will be required.