Halo nevus and vitiligo are known to be associated with immunologic defect that result in typical skin lesions. Random shapes and sizes of whitish patches, depending on the type, are featured in vitiligo. Halo, on the other hand, presents by surrounding the previous pigmented lesion leaving a whitish-halo-like appearance. The mechanisms underlying these entities remain to be elucidated. Various immunological responses along with biomechanical activities suggest causal relationship between the two diseases. A 6-year-old male patient was recently presented with multiple whitish patches on the various parts of the body in a Koebner phenomenon manner. A noticeable hairy congenital melanocytic nevus surrounded a well-demarcated halo of depigmentation was also observed. Clinical and pathological findings were conclusive of as halo nevus with multiple concurrent vitiligo. The pathogenic relationship between the two entities must be underlined since the nature of disease progression is associated and the respective management may also be altered accordingly.

The effect of Na-Hyaluronan(Na-HA) on hemidesmosome morphogenesis was evaluated in n-heptanol induced corneal epithelial wounds, Epithelial wounds were produced by applying a 5.5mm round filter paper, soaked in n-heptanol, on the central cornea for 60 seconds. 1% Na-HA in phosphate buffered saline(PBS) or PBS saline were instilled 4 times a day for 3 days. Epithelial healing rates determined during the first two days were not altered by Na-HA. However, the number of hemidesmosome in the central cornea, which was counted in the basement membrane, significantly increased by the treatment with 1% Na-HA, being 10.0±1.1 in the 1% Na-HA treated group and 6.5±2.5 in the control group. The results suggest that topically applied 1% Na-HA may enhance the formation of hemidesmosome in n-heptanol wounded cornea.

The effect of topically applied 1% sodium hyaluronate on the healing of a standardized corneal alkali wound was evaluated. Central comeal alkali wound was produced in one eye of 60 albino rabbits by applying a 5.5mm round filta paper, soaked in IN NaOH, for 60 seconds. 1% sodium hyaluronate in the treatment group and PBS in the control group were initilled 4 times per day for 2 days, 1 week, and 3 weeks. Epithelial healing was assessed morphometrically from 1 week specimens. Stromal healing was evaluated by measuring the ratio of PMN and keratocyte in the areas of the cental and marginal corneas. A positive healing influence was observed in the epithelium. The stromal PMN infilteration was suppressed, especially, in the central area, in the 1% sodium hyaluronate treated groups when compared with the control group.