, Youn-Jin Kim, Hyun-Joo Kim, Soyun Cho, Kyu-Kwang Whang, Jeong-Hee Hahm We report a case of type III hyperlipoproteinemia associated with tuberous xanthoma, which is improved by treatment with lovastatin and bezafibrate. A 34-year-old female patient visited our clinic for evaluation of multiple yellowish-brown papulonodules on the kness, elbows and palms. Serum lipid examination showed an abnormal elevation of serum cholesterol and triglyceride. Lipoprotein electrophoresis showed a single peak at pre-β and β portion without separation. The biopsh specimen from a nodule on the knee and a papule on the palm revealed characteristic findings of xanthoma. We diagnosed the case as type III hyperlipoprotei-nemia. After 3 months of treatment with diet restriction, lovastatin and bezafibrate, the serum levels of cholesterol and triglyceride were reduced to normal level. The skin lesion of the palm showed complete regression and ones on both knees and elbows were moderate improvement.
, Moon-Jung Kim, Soyun Cho, Kyu-Kwang Whang, Jeong-Hee Hahm This study attempts to evaluate the clinical manifestations and causative drugs of drug eruptions at Ewha Womans University Tongdaemun Hospital by retrospective study of outpatients, inpatients and consulted patients(number : 121, duration : 1994. 1 - 1999. 5).
1) Most drug eruptions occurred in patients at the age of 20 - 39 years old.
2) The cutaneous manifestations of drug eruptions in the order of frequency were as follows : exanthematous eruption, fixed drug eruption, acneiform eruption, purpura, urticaria, bullous eruption, lichenoid eruption, Stevens-Johnson syndrome, and acute generalized exanthemic pustulosis.
3) Drug eruption developed most frequently from 24 hours to 3 days of drug intake.
4) Most common causative drugs were antibiotics, followed by antipyretics and analgesics.
5) Laboratory abnormalities were leukocytosis(22.5%), eosinophilia(14.5%), abnormal AST/ALT(11.4%), abnormal IgE titer(8.3%), and leukopenia(5.6%).
The most frequent clinical feature of the drug eruption were exanthematous in nature and the most common causative drugs were antibiotics, as suspected.
Since too many patients take various unidentified drugs at drug stores in Korea, physicians need to exercise special care in prescribing drugs and evaluating patients with drug eruption.
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