Two groups of patients were studied to evaluate the hemostatic effects of high-does aprotinin in open heart operations. Aprotinin group patients(n=8) received aprotinin during entire surgical procedure. The other group patients(n=10) were served as control. Two groups were homogenous for base variables and for cardiopulmonary bypass duration. Post operative bleeding was lower in aprotinin group(mean, 599ml) than control group(886ml, p<0.05). The need for banked blood decreased in aprotinin group(aprotinin group mean, 106ml ; control group mean, 387ml). Perioperative hemoglobin & platelet counts were similar each other.

We concluded that the use of high-does aprotinin was safe and effective. It decreased blood loss and reduced the need for banked blood in open heart operations.