Subepithelial tumors in the upper gastrointestinal (GI) tract are often detected during nationwide endoscopic gastric cancer screening in Korea. Most GI lipomas are asymptomatic and do not necessitate further treatment. However, large tumors may lead to complications such as bowel obstruction, intussusception, and bleeding. These GI lipomas require endoscopic or surgical resection. On radiological examination, GI lipomas typically manifest as hypodense lesions with similar density to that of fat tissue. White-light endoscopy generally reveals a yellowish subepithelial tumor exhibiting a positive cushion sign, while endoscopic ultrasonography shows a homogeneous hypoechoic mass within the third layer of the GI tract. We present the case of an 81-year-old woman with symptomatic duodenal lipoma following endoscopic resection.

Benign Symmetric Lipomatosis is a lesion characterized by symmetric and diffuse growth of adipose tissue.

It is commonly found in the posterior neck or upper trunk, but oral involvement is extremely rare.

Authors experienced a case of Benign Symmetrical Lipomatosis of tongue. The tumors was completely removed out under the general anesthesia.

Histopathologic examination verified Benign Symmetric Lipomatosis of tongue. So, authors report this case with brief review of literatures.