Ewha Medical Journal

"Sanghui Park"

Original Article

[English]

Prevalence of BRAF and NRAS Mutations and a Comparative Analysis in Primary and Metastatic Melanoma of Korean Patients: Deok Young Choi, Sang Pyo Lee, Sanghui Park; Ewha Med J 2014;37(1):30-35. Published online March 25, 2014; DOI: https://doi.org/10.12771/emj.2014.37.1.30

Abstract
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Objectives

The aim of this study is to verify the status and the clinical significance of BRAF and NRAS mutations in patients of one of the university hospitals in Korea.

Methods

Polymerase chain reaction (PCR) amplification and direct sequencing were performed for the analysis of melanoma samples (n=22) for the detection of mutations in exon 15 of the BRAF gene, and exons 2 and 3 of the NRAS gene in genomic DNA. Mutations of the BRAF gene were correlated with the clinicopathologic features of patients and the BRAF mutation status was compared in 18 paired primary and metastatic tumors.

Results

Incidence of somatic mutations within the BRAF and NRAS genes was 27.3% (6/22) and 0% (0/22), respectively. Age, gender, Breslow thickness, and ulceration did not show correlation with BRAF mutations. Among 18 patients with metastasis, BRAF mutation was detected in 22.2% of cases (4/18), and all four cases with BRAF mutations were identified in metastatic lymph node tissues. BRAF mutations were only found in lymph node metastases, which was statistically significant (28.6% vs 0%, P<0.01).

Conclusion

The incidence of BRAF mutation is as low as in other Asian reports and the NRAS mutation was not found in patients of our institute.

Citations

Citations to this article as recorded by

Survival rates for invasive cutaneous malignant melanoma in South Korea in accordance with the Eighth edition AJCC Cancer Staging Manual: A retrospective single center study
Seon Hwa Lee, Gi Ung Ha, Hyun Ji Lee, Ho Yun Chung, Seung Huh, Dae-Lyong Ha, Kyung Duck Park, Yong Hyun Jang, Weon Ju Lee, Seok-Jong Lee, Jun Young Kim
Indian Journal of Dermatology, Venereology and Leprology.2023; 90: 163. CrossRef
The frequency and clinicopathological significance of NRAS mutations in primary cutaneous nodular melanoma in Indonesia
Hanggoro Tri Rinonce, Deflen Jumatul Sastri, Fita Trisnawati, Bidari Kameswari, Paranita Ferronika, Irianiwati
Cancer Reports.2022;[Epub] CrossRef
Concordance of somatic mutation profiles (BRAF, NRAS, and TERT) and tumoral PD-L1 in matched primary cutaneous and metastatic melanoma samples
Shi Yang, Dominick A. Leone, Asok Biswas, April Deng, Drazen Jukic, Rajendra Singh, Uma Sundram, Meera Mahalingam
Human Pathology.2018; 82: 206. CrossRef

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Review Article

[English]

Renal Cell Neoplasms: Recent Advances: Sanghui Park, Jae Y. Ro; Ewha Med J 2014;37(1):16-25. Published online March 25, 2014; DOI: https://doi.org/10.12771/emj.2014.37.1.16

Abstract
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The incidence of renal cell neoplasms has been increased in worldwide as well as in Korea. Even though the World Health Organization (WHO) Classification of renal tumors (2004) is currently used, new entities require to be added in the updated classification because of recent modification with our understanding of the molecular biology and different clinical behavior of new renal tumors. In this review, recently described tumors and candidate entities will be discussed. It is of importance to know these new entities for the proper diagnosis, treatment, and their prognosis.