The Ewha Medical Journal

"Sung Eun Hur"

Original Article

[English]

Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women: Sa Ra Lee, Sung Eun Hur, Hye Sung Moon, Hyung-Lae Kim, Hye Won Chung; Ihwa Ŭidae chi 2003;26(2):91-96. Published online June 30, 2003; DOI: https://doi.org/10.12771/emj.2003.26.2.91

Abstract
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Objective

To investigate whether polymorphism of gene encoding estrogen receptor-α is associated with the risk of endometriosis in Korean women.

Material and Methods

We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's estrogen receptor-α genotype.

Results

The distridution according to PvuII genetic polymorphism of estrogen receptor-α were as follows. PP, Pp and pp were 14.7%(20 women), 39.0%(53 women) and 46.3%(63 women) in the study group and 13.9%(35 women), 38.6%(98 women) and 47.4%(119 women) in the control group, respectively. There was no significant difference between the study group and the control group.

Conclusion

The results suggest that estrogen receptor-α genetic polymorphism may not be associated with the development of endometriosis in Korean women.

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Case Report

[English]

A Case of Behçet's Disease in Pregnancy: Ho Seun Lyoo, Sung Eun Hur, Han Moie Park, Mi Young Park, Young Ju Kim; Ihwa Ŭidae chi 2001;24(1):51-55. Published online March 31, 2001; DOI: https://doi.org/10.12771/emj.2001.24.1.51

Abstract
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This 31 years old female patient visited our hospital on July 2000, with complaint of painful ulceration on vulvar with withish coated membrane and oral mucosa ulceration at 28 weeks of pragnancy.

Behҫet's disease is an inflammatory disorder of unknown cause, characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesion.

We are present a case of Behҫet's disease in pregnancy with a brief review of literature.