The infiltrative carcinoma of stomach is reported to difficult to diagnosis by gastroscopic examination only, because of a few change of mucosa. So the tumor is diagnosed with the aid of gastroscopic multiple biopsy findings. We experienced a case of infiltrative carcinoma of stomach, which was similar to hypertrophic gastritis. The tumor was confirmed by the biopsy and operation finding. The general concept of infiltrative carcinoma of stomach with the brief review of literature is discussed here.