, Ki Bum Myung We experienced a case of venous hemangioma, which was clinically suspected as a granuloma pyogenicum but confirmed histopatholoically. The patient was a 27-year-old woman, who showed erythematous bluish nontender nodules on the right nostril and ala nasi. Histopathologic examination showed blood vessels with thick fibromusclar wall and thin wall in the dermis. The blood vessel with thick wall was lined by a single layer of endothelial cells and lacked elastic fibers on Verhoeff van Gieson stain.
She was treated with surgical excision, laser therapy(SPTL-1) and intralesional triamcinolone acetonide injection.
, Yeon Soon Lim, Ki Bum Myung We report a case of Becker's nevus with smooth muscle harmatoma in a 24-year-old man, who showed localized excessive-hairy, dark brown colored patch including pin-head sized follicular papules on the left side of bucca, mandible and neck. Histologic examination revealed hyperpigmentation of the basal layer of epidermis and hyperplasia of smooth muscle bundles in the dermis.
, Ka Youn Chang, Yeon Soon Lim, Hae Young Choi, Ki Bum Myoung Granular cell tumor(GCT) is an uncommon tumor characterized clinically by an asymptomatic, solitary nodule in the tongue and skin, especially head and neck region. Histopathologically the broad fascicles of tumor cells infiltrate the dermis and the tumor cells are characterized by plump cells with faint eosinophilic, granular cytoplasm.
The origin of cells has been debated for decades. However electron microscopic and immunohistochemical studies strongly support a Schwann cell origin.
We report a case of granular cell tumor arising from the anterior chest of 12-year-old healthy girl, which exhibited the distinctive histopathologic appearance and also reactive with PAS, S-100, and NSE.
, Hae Young Choi, Ki Bum Myung, Jeong Hee Hahm, Woon Sup Han On previous reports about the relationship between herpes simplex virus(HSV) & erythema multiforme(EM), subjective specimens were taken from target lesions and papules of herpes-associated EM or recurrent EM of unknown etiology. PCR-positive specimen were found in target lesion of idiopathic EM and even drug induced EM. But biopsy was actually performed when the clinical finding is atypical and so diagnosis is not certain with only clinical finding. In non-classic type of erythema multiforme without herpes associated history or recurrent episode, we try to evaluate the clinical and histopathologic findings and to detect the DNA of herpes simplex virus.
We clinically and histopathologically observed the 29 cases of non-classic type of erythema multiforme through the clinical photographics, clinical charts and telephone visiting. And we also tested 29 paraffin-embedded tissues from non-classic type of erythema multiforme by PCR with two nested primer pairs.
The results are as follows :
1) There are not specific difference according to age and sex.
2) The most frequent clinical type was the diffuse type(55.2%), followed by the acral type(24.1%) and central type(20.7%).
3) The major cause was idiopathic(72.4%), followed by the drug(27.6%).
4) There were various findings in clinical manifestation, including maculopatch, palulopla-que, wheal-like papule, vesicle-bullae, purpuric macule and papule and urticaria.
5) Histologically, we observed necrotic keratinocyte(48.3%) and spongiosis, exocytosis and vacuolization of basal cell in most cases. Eosinophilic infiltration, pigmentary incontinence and RBC extravasation were also seen.
6) The HSV positive specimens were fund in 2 cases(6.9%).
Although herpes simplex virus infection is a major contributing factor to most cases of erythema multiforme, our data supports the finding that it is not so important in non-classic type of erythema multiforme.
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