The production of basic fibroblast growth factor(bFGF), which is known to have strong angiogenic activity in gastric cancer, was evaluated.

Using Alkaline phosphoatase-labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated with in situ hybridization method in 9 fresh advanced gastric cancer tissues.

In situ Hybridization of bFGF mRNA showed positive reaction in 8 of 9 patients.

In view of profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.