Original Article

The Effects in Colonic Body Temperature in Rats Injected Intracerebrally with PCPA & 5,7-DHT

Young Sook Pae, Hea-Young Park*
Author Information & Copyright
Department of Pharmacology, School of Medicine, Ewha Womans University, Korea.
*Department of Industrial Pharmacy, School of Pharmacy, Ewha Womans University, Korea.

Copyright ⓒ 1993. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Simonic(1988) have investigated that hypothermic effect of oholinornimetics is mediated through an activation of muscarine cholinergic receptors. And also, Yamada(1987) injected trytamine into the lateral cerebroventricle in mice and observed hypothermic through 5-HT1 receptor.

We have previously reported that PCPA(a serotonin depletor), has reduced 5-HT contents gradually, but had a marked reduction in Ach contents in the cortex and hippocampus.

After injection of PCPA and 5,7-DHT, a serotonergic toxin into the cerebroventricle in rats, we observed the colonic body temperature and Ach contents of cerebral cortex.

The results of our study are as follows :

1) Ach contents in the cortex were decreased significantly on the 3rd day & 7th day after PCPA i.c.v. injection.

2) Ach contents in the cortex were not changed on the 3rd day & 7th day after 5,7-DHT i.c.v. injection.

3) Increase in colonic body temperature was markedly observed in rats on 3rd day & 7th day after received intracerebral PCPA injection. During handling with rectal probe insertion there is a small changes of colonic body temperature with time.

4) Increase in colonic body temperature was observed in rats on 3rd day after received intracerebral 5,7-DHT injection. During handling with rectal probe insertion there is a small changes of colonic body temperature with time.

So, we concluded that serotonin depletion could cause a decrease in Ach contents of the cortex and also increase in colonic body temperature via cholinergic system in the brain.