Original Article

The Clinical Value of Rapid Urease Test(CLO Test) for the Detection of Helicobacter Pylori in Gastric Biopsy Specimens of Duodenal Ulcer Patients

Doe Young Kim, Sung Sook Kim
Author Information & Copyright
Department of Internal Medicine, College of Medicine, Ewha Womans University, Korea.
Department of Pathology, Medical of College, Ewha Womans University, Korea.

Copyright ⓒ 1995. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015



This study was aimed to assess the value of rapid urease test (CLO test) for thedetection of Helicobacter (H.) pylori in patiens with duodenal ulcer and compare its resultwith histological technique using H & E stain.


The CLO test and histological study were done using three pieces of antral biopsyspecimens in 46 patients with duodenal ulcer. The clinical histories such as smoking, bloodtype or the previous use of NSAIDs were obtained from the patients.


1) The CLO test was positive in 35 (76.1%) among 46 patients with duodenal ulcer, while H & E stain was positive in 91.3%.

2) When H & E stain positive case was diagnosed as H. pylori infection, the sensitivity of CLO test was 81.0%, the specificitry 75.0% and the predictability was 97.1%.

3) The grading of gastric inflammation showed that the higher the histologogical grade, the more likely CLO test would be positive.

4) There were no differences of recurring history of duodenal ulcer, smoking rate, NSAIDs history and blood type between 34 cases of both CLO and H & E positive cases and 3 cases ofboth negative cases except a mild increasing tendency of age, male predominance and scarringstage of duodenal ulcer in both negative cases.


The CLO test is a rapid and simple test, but it should require other complementary diagnostic tests to increase the sensitivity and specificity.

Keywords: Helicobacter pylori; Rapid urease test(CLO test); Duodenal ulcer