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"Iron"

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Special topic: role of institutes related to the occupational and environmental diseases in Korea

[English]
Environmental disease monitoring by regional Environmental Health Centers in Korea: a narrative review
Myung-Sook Park, Hwan-Cheol Kim, Woo Jin Kim, Yun-Chul Hong, Won-Jun Choi, Seock-Yeon Hwang, Jiho Lee, Young-Seoub Hong, Yong-Dae Kim, Seong-Chul Hong, Joo Hyun Sung, Inchul Jeong, Kwan Lee, Won-Ju Park, Hyun-Joo Bae, Seong-Yong Yoon, Cheolmin Lee, Kyoung Sook Jeong, Sanghyuk Bae, Jinhee Choi, Ho-Hyun Kim
Ewha Med J 2025;48(1):e3.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e3

This study explores the development, roles, and key initiatives of the Regional Environmental Health Centers in Korea, detailing their evolution through four distinct phases and their impact on environmental health policy and local governance. It chronicles the establishment and transformation of these centers from their inception in May 2007, through four developmental stages. Originally named Environmental Disease Research Centers, they were subsequently renamed Environmental Health Centers following legislative changes. The analysis includes the expansion in the number of centers, the transfer of responsibilities to local governments, and the launch of significant projects such as the Korean Children’s Environmental Health Study (Ko-CHENS ). During the initial phase (May 2007–February 2009), the 10 centers concentrated on research-driven activities, shifting from a media-centered to a receptor-centered approach. In the second phase, prompted by the enactment of the Environmental Health Act, six additional centers were established, broadening their scope to address national environmental health issues. The third phase introduced Ko-CHENS, a 20-year national cohort project designed to influence environmental health policy by integrating research findings into policy frameworks. The fourth phase marked a decentralization of authority, empowering local governments and redefining the centers' roles to focus on regional environmental health challenges. The Regional Environmental Health Centers have significantly evolved and now play a crucial role in addressing local environmental health issues and supporting local government policies. Their capacity to adapt and respond to region-specific challenges is essential for the effective implementation of environmental health policies, reflecting geographical, socioeconomic, and demographic differences.

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Original Article

Original Articles

[English]
Comparative Analysis of Health Patterns and Gaps due to Environmental Influences in South Korea and North Korea, 2000–2017
Yoorim Bang, Jongmin Oh, Eun Mee Kim, Ji Hyen Lee, Minah Kang, Miju Kim, Seok Hyang Kim, Jae Jin Han, Hae Soon Kim, Oran Kwon, Hunjoo Ha, Harris Hyun-soo Kim, Hye Won Chung, Eunshil Kim, Young Ju Kim, Yuri Kim, Younhee Kang, Eunhee Ha
Ewha Med J 2022;45(4):e14.   Published online October 31, 2022
DOI: https://doi.org/10.12771/emj.2022.e14
ABSTRACT Objectives:

To conduct a comparative study of children’s health in South Korea versus North Korea focusing on air pollution.

Methods:

We used annual mortality rate, prevalence, and environmental indicators data from the World Bank and World Health Organizations (WHO). Trend analysis of the two Koreas was conducted to evaluate changes in health status over time. Spearman’s correlation analysis was used to find out the correlation between environmental indicators and children’s health status.

Results:

We found a distinct gap in children’s health status between the two Koreas. While North Korea reported a higher death rate of children than South Korea, both showed a decreasing trend with the gap narrowing from 2000 to 2017. The prevalence of overweight and obesity increased and that of thinness decreased in both Koreas. Except PM2.5 exposure, South Korea reported higher figures in most indicators of air pollutant emissions (South Korea, mean (SD)=28.3 (2.0); North Korea, mean (SD)=36.5 (2.8), P-value=0.002).

Conclusion:

This study empirically discovered the gaps and patterns of children’s health between South Korea and North Korea. North Korean children experienced more severe health outcomes than children in South Korea. These findings imply that epigenetic modification caused by environmental stressors affect children’s health in the two Koreas despite similar genetic characteristics. Considering the gaps in children’s health between the two Koreas, more attention and resources need to be directed towards North Korea because the necessary commodities and services to improve children’s health are lacking in North Korea.

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Case Report

[English]
Acquired Hypopituitarism in Diamond-Blackfan Anemia
Ji Yun Yun, Jung Eun Choi, Hae Soon Kim, Kyung Ha Ryu
Ewha Med J 2020;43(4):65-69.   Published online October 31, 2020
DOI: https://doi.org/10.12771/emj.2020.43.4.65

Diamond-Blackfan anemia (DBA) is a rare, inherited bone marrow failure syndrome that manifests as anemia in early infancy. Blood transfusion is a critical factor for survival. However, blood transfusions can result in iron overload. Endocrinopathies, hepatic cirrhosis, and cardiomyopathy are the most common complications of iron overload. Here, we report the case of an 18-year-old boy with DBA with hyperglycemia, short stature, and absence of puberty. The patient showed endocrine dysfunction associated with iron overload caused by repeated transfusions. He was eventually diagnosed with acquired hypopituitarism and was placed on testosterone replacement therapy. Endocrine dysfunction is common in patient with DBA, with an early manifestation of symptoms, even in teenage years. Patients receiving corticosteroid treatment or those in remission may also exhibit endocrine dysfunction, although its prevalence is the highest among chronic transfusion patients. Ongoing monitoring and evaluation of growth and pubertal development are needed for better management of these disorders.

Citations

Citations to this article as recorded by  
  • RPS24 haploinsufficiency impairs erythropoiesis in the Diamond–Blackfan anemia zebrafish model via the STAT6–SATB1 pathway
    Soyul Ahn, Chang-Kyu Oh
    Biochemical and Biophysical Research Communications.2025; 756: 151563.     CrossRef
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  • 1 Web of Science
  • 1 Crossref

Review Article

[English]
Systematic Review on Sanitary Pads and Female Health
Jingang Woo, Soyeon Kim, Haesoon Kim, Kyoung Sook Jeong, EunMee Kim, Eunhee Ha
Ewha Med J 2019;42(3):25-38.   Published online July 31, 2019
DOI: https://doi.org/10.12771/emj.2019.42.3.25

The majority of South Korean females use sanitary pads, which contain various organic solvents which could be excreted before and during their menstruation. However, they are not provided with findings from studies about the health effects of sanitary pads. Therefore, this study aims to establish a list of potential health hazards of sanitary pads and address the need for further extensive research by pointing out the limitations of the previous literature. A systematic review was adopted to conduct quantitative and qualitative reviews based on the PRISMA (preferred reporting items for systematic reviews and meta-analyses). Studies from electronic databases such as PubMed, RISS, and Google Scholar were retrieved for the final analyses. In accordance with our findings, we proposed a set of limitations of the previous studies. A systematic review revealed that there were effects of sanitary pads on vaginal or vulvar skin, endometriosis, and vaginal microflora. The review also revealed that organic solvents, which sanitary pads are composed of, bring potential harmful effects on pregnancy, autoimmune disease, cardiovascular disease, and neurological development. Social environments such as hygiene use or puberty education also turned out to affect female health. It was inferred that a lack of non-occupational and domestic studies reflecting the distinguishing features of sanitary pads with a reliable sample size remains as an important limitation. This study suggests that organic solvents in sanitary pads may increase some health risks bringing reproductive, autoimmune, cardiovascular, and neurological effects. Due to a lack of studies, a more extensive study can contribute to the public health of South Korean females.

Citations

Citations to this article as recorded by  
  • Elucidating the role of zinc oxide in dermatitis of varied etiology across the age spectrum: a comprehensive review
    Sailesh Gupta, Srichand G. Parasramani
    International Journal of Research in Medical Sciences.2025; 13(4): 1759.     CrossRef
  • Addressing the commercial determinants of menstrual health: a call to regulate menstrual product manufacturers
    Céline Brassart Olsen
    Health Promotion International.2024;[Epub]     CrossRef
  • The condition of women frequently changing sanitary pads in 28 cities of China: a cross-sectional study
    Jiachen Sun, Shuwen Bai, Qi Li, Meizhen Zhao, Lina Ge, Shuang Zang
    Reproductive Health.2024;[Epub]     CrossRef
  • Resource recovery from soiled sanitary napkin waste—a state-of-the-art review
    Muhammad Sajeed Abdul Hameed, Sreya Pacheeri Sreedharan, Purushothaman Sivapragasam, Samarshi Chakraborty, Chitra Devarajulu, Krishnasamy Sivagami
    Environmental Science and Pollution Research.2024; 31(21): 30336.     CrossRef
  • “Ritual Purity” Reimagined: Eco-Friendly Menstrual Practices and Emotional Well-being in Muslim Women
    Shahida
    Women's Reproductive Health.2024; 11(4): 767.     CrossRef
  • Impact of Hazardous Chemical compounds on Reproductive System Reported in Sanitary Products
    Mayuri K. Gaikwad, Mohini Upadhye, Dhanashri Borchate, Nilam Jankar
    Research Journal of Pharmacology and Pharmacodynamics.2023; : 112.     CrossRef
  • Menstrual cup webinar series: A developing model of modified pre- and post-tests in the online teaching-learning of primary health care workers
    Arti Gupta, Rajeev Aravindakshan, Vijayan Sharmila, Venkatashiva B Reddy, Yamini Marimuthu, Navya Krishna Naidu
    Journal of Education and Health Promotion.2023;[Epub]     CrossRef
  • A novel banana fiber pad for menstrual hygiene in India: a feasibility and acceptability study
    Krishnashree Achuthan, Sharanya Muthupalani, Vysakh Kani Kolil, Anju Bist, Krishna Sreesuthan, Aswathy Sreedevi
    BMC Women's Health.2021;[Epub]     CrossRef
  • Development and uncertainty estimation of cryogenic homogenization and static headspace–gas chromatography–mass spectrometry method for the simultaneous determination of twelve toxic volatiles in disposable menstrual products
    Minyeong Kim, Hye-Jin Park, Ok-Nam Bae, Seung-Hoon Baek
    Microchemical Journal.2020; 158: 105291.     CrossRef
  • 518 View
  • 11 Download
  • 5 Web of Science
  • 9 Crossref
Original Articles
[English]
Survey on Awareness for Environmental Health Risk of Fetus and Infant in Reproductive-aged Women
Jiyoung Shin, Eunkyo Park, Jungeun Shin, Eun-Hee Ha
Ewha Med J 2018;41(2):35-43.   Published online April 30, 2018
DOI: https://doi.org/10.12771/emj.2018.41.2.35
Objectives

The accumulated evidence shows that adult disease may have origins during the fetal period and maternal environmental exposure may affect fetus and infant health. To assess the environmental health of fetus and infants and examine women's concerns about environmental health, we designed and conducted an environmental health survey in reproductive-aged women in 2011.

Methods

A stratified multi-stage design was adopted for our survey, and 1,000 reproductive-aged women aged 25 to 39 years participated. The participants were asked to complete an electronic questionnaire using the computer-assisted web interviewing method. All the participants were married woman, and 80% had experienced pregnancy before completing the survey.

Results

In the study, 86.3% of the participants responded that they are worried about the environmental problems that may affect the fetus and infant. The participants responded that they were most worried about global warming and climate change (36.2%), electromagnetic waves (31.4%), and endocrine disrupting chemicals (25.1%). Moreover, participants responded that environmental problem can cause children's allergic disease, such as atopic dermatitis, metabolic syndrome and growth development.

Conclusion

We found reproductive-aged women have high awareness of children's environmental health. We also recommended that additional surveys on mother and child environmental health be conducted to make a health policy for women, fetus and infant.

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[English]
A Study for Serum Iron Level in Neuroleptic Induced Akathisia
Eun Hee Jo, Young Chul Kim, Haing Won Woo
Ihwa Ŭidae chi 1997;20(2):239-246.   Published online July 24, 2015
DOI: https://doi.org/10.12771/emj.1997.20.2.239
Objectives

Neuoleptic induced akathisia is an unsual state of subjective feeling of tension to move and objective motor restlessness, so frequently results in non-compliance. Several studies have suggested that akathisia is associated with low serum iron but there is no general agreement nowadays. Author investigated whether akathisic patients had lower indices of serum iron status than matched non-akathisic controls by 2 weeks-prospective study.

Methods

The subjects were 30 inpatients who were receiving antimycotic medication. Akathisia severity was measured by Chouinard rating scale, then 15 akathisic patients were matched with 15 non-akathisic controls for age, sex, length of illness, duration of treatment, the highest dosage of natipsychotic medication, and use of antiparkinsonian agents. The frequency of acute dystonia and AIMS for other extrapyramidal side effects were examed, also. Venous blood samples of all subjects were analysed for serum Fe, ferritin, TIBC on the 1st, 7th, and 14th medication day.

Results

Sociodemographic factors, such as, sex, mean age, and clinical characteristics such as, length of illness, duration of treatment, the kinds and mean dosage of neuroleptics, were not different between the akathisia and the control group(p>0.05). The akathisic patients had significantly lower level of serum Fe than the control on 14th day(p<0.05), but no significant decrease during the 2 weeks follow-up(p>0.05). The frequency of acute dystonia, and anticholinergic medication were not different between the two groups(p>0.05), but AIMS score was significantly higher in the akathisia group(p<0.05).

Conclusion

Neuroleptic induced akathisia may be related to the low serum Fe. So, this study supports that low serum iron, via dopamine(D2) receptor hypofunction, increases the susceptibility to akathisia on antipsychotic medication.

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[English]
Regulation of p53 Genes by Ferritin Light Chain: Preliminary Study
Sun Young Yi
Ihwa Ŭidae chi 2008;31(1):9-14.   Published online June 30, 2008
DOI: https://doi.org/10.12771/emj.2008.31.1.9

No abstract available in English.

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