The current issue of the Ewha Medical Journal presents a diverse and clinically relevant collection of articles that span medical education, emerging therapeutics, rare disease presentations, and diagnostic challenges.

The 2 review articles offer evolving perspectives spanning both medical education and clinical therapeutics. The first examines “jokbo-based learning” as a form of hidden curriculum in Korean medical education, exploring its dual role in fostering efficiency while raising concerns about depth of learning and academic integrity. The second provides an evidence-based synthesis of probiotic use in gastrointestinal disorders, with particular attention to strain-specific effects and sex-based differences—an important yet underexplored dimension of microbiome-targeted therapy.

Four case reports further illustrate the diagnostic and clinical breadth of this issue. These include recurrent thrombotic events associated with MTHFR (methylenetetrahydrofolate reductase) compound heterozygosity; a rare intrasellar persistent trigeminal artery with atherosclerotic changes causing symptomatic posterior circulation insufficiency; a symptomatic elastofibroma dorsi successfully managed with surgical excision; and an atypical presentation of chronic urticaria characterized by nociceptive pain responsive to immunoglobulin/histamine complex therapy. Together, these cases suggest the value of integrating genetic, anatomical, radiologic, and immunologic perspectives in clinical reasoning.

The “Image and Solution” article presents a diagnostically challenging case of skull base granulomatosis with polyangiitis manifesting as multiple cranial neuropathies. This report emphasizes the clinicoradiologic correlation—particularly in seronegative presentations—and the need for early recognition of potentially reversible inflammatory conditions.

Finally, a Letter to the Editor offers a practical perspective on incorporating generative artificial intelligence into medical education. The author addresses key considerations for responsible implementation, including domain-specific validation, mitigation of hallucination and bias, and the development of flexible, practice-oriented training strategies.

Taken together, this issue reflects the ongoing integration of emerging knowledge with real-world clinical application, reinforcing the enduring importance of critical appraisal, and adaptability in contemporary medical practice. We hope the articles here prove useful in both your studies and practice.

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